Abstract Background The optimal stage for initiating antiretroviral therapies in HIV-1 bearing patients is still a matter of debate.Methods We present computer simulations of HIV-1 infection aimed at identifying the pro et contra of immediate as compared to deferred Highly Active Antiretroviral Therapy (HAART).Results Our simulations highlight that
Abstract: Patients with hematologic malignancies or nonmalignant diseases may undergo allogeneic hematopoietic cell transplantation (HCT), which represents a potential curative treatment.However, they are still at risk of life-threatening complications, such as relapse, acute graft-versus-host disease, and opportunistic infections.These complicatio
In extensive livestock production, high densities may inhibit regulation processes, maintaining high levels of intraspecific competition over time.During competition, individuals typically modify their behaviours, particularly feeding and bite rates, which can therefore be used as indicators of competition.Over eight consecutive seasons, we investi
Targeted therapies are the state of the art in oncology today, and every year new Tumor-associated antigens (TAAs) are developed for preclinical research and clinical trials, but few of them really change the therapeutic scenario.Difficulties, either to find antigens that are solely expressed in tumors or the generation of good binders to these ant